o-Nitrobenzaldehyde 552-89-6

o-Nitrobenzaldehyde (CAS 552-89-6), also known as 2-Nitrobenzaldehyde, is an important aromatic building block used in pharmaceutical intermediate synthesis and fine chemical manufacturing. Its ortho-positioned nitro and aldehyde groups provide versatile reaction sites for constructing nitrogen-containing heterocyclic compounds.

One of its most significant applications is the synthesis of Nifedipine, a 1,4-dihydropyridine calcium channel blocker. This makes o-Nitrobenzaldehyde an important starting material for pharmaceutical manufacturers developing dihydropyridine-based compounds.

Industrial preparation of 2-Nitrobenzaldehyde commonly involves the controlled oxidation of 2-nitrotoluene. Unlike direct nitration of benzaldehyde, which predominantly produces the meta-substituted isomer, this route preserves the required ortho-substitution pattern.

Key manufacturing stages include:

• Starting Material Preparation: 2-Nitrotoluene is selected as the aromatic precursor for introducing the aldehyde functionality.

• Side-Chain Oxidation: The methyl group is selectively oxidized into an aldehyde group while retaining the aromatic nitro substituent.

• Reaction Selectivity: Oxidant selection, reaction temperature, and conversion control help minimize overoxidation and unwanted by-products.

• Product Isolation: Appropriate extraction, phase separation, and concentration techniques are applied to recover the crude product.

• Crystallization and Purification: Controlled crystallization and recrystallization help improve purity and reduce residual organic impurities.

  
  

These process parameters are important for obtaining consistent 2-Nitrobenzaldehyde quality for downstream pharmaceutical synthesis.

A major application of o-Nitrobenzaldehyde CAS 552-89-6 is the Hantzsch synthesis of 1,4-dihydropyridine derivatives.

In the synthesis of Nifedipine, the aldehyde group reacts with methyl acetoacetate and an ammonia-containing reactant system to construct the dihydropyridine ring. The ortho-nitrophenyl group becomes part of the resulting molecular structure.

Beyond Nifedipine synthesis, this compound is also used in the preparation of other pharmaceutical intermediates, organic heterocycles, and specialty chemicals. Its photolabile 2-nitrobenzyl functionality also makes it useful in photoremovable protecting-group chemistry.

For international buyers seeking an o-Nitrobenzaldehyde Supplier China, Rocky Pharm provides pharmaceutical raw material sourcing services through established Chinese supply channels.

We support pharmaceutical intermediate producers, API developers, and chemical distributors with sourcing solutions based on required purity, specifications, and purchasing quantities.

As an o-Nitrobenzaldehyde Bulk Supplier sourcing partner, Rocky Pharm welcomes inquiries for both regular procurement and larger-volume requirements.

Contact Rocky Pharm for CAS 552-89-6 product information, current supply options, and a competitive quotation.