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| Product Information |
Product Name: | Lycopene |
Synonyms: | 4,4-CAROTENE;LYCOSOURCE;LYCOPENE;JARCOPENE(TM);2,6,10,14,19,23,27,31-OCTAMETHYL-DOTRIACONTA-2,6,8,10,12,14,16,18,20,22,24,26,30-TRIDECAENE;PSI,PSI-CAROTENE;Y,Y-CAROTENE;E 160d |
CAS: | 502-65-8 |
MF: | C40H56 |
MW: | 536.87 |
EINECS: | 207-949-1 |
 | |
| COA Of Lycopene |
Item | Specification | Result | Test Method |
Physical Properties | — | — | — |
Appearance | Dark Red Powder | Complies | Visual Inspection |
Odor | Characteristic | Complies | Organoleptic Test |
Sieve Analysis | NLT 100% pass 80 mesh | Complies | USP<786> Sieve Test |
Chemical Analysis | — | — | — |
Assay (Lycopene by HPLC) | ≥10% | 10.35% | HPLC |
Moisture | ≤3% | 1.95% | Karl Fischer Titration |
Ash | ≤1% | 0.53% | USP<281> Gravimetric Analysis |
Heavy Metals | — | — | — |
Heavy Metals (Total) | ≤10 ppm | <10 ppm | ICP-MS |
Arsenic (As) | ≤2 ppm | <2 ppm | ICP-MS |
Lead (Pb) | ≤1 ppm | <1 ppm | Atomic Absorption Spectroscopy (AAS) |
Cadmium (Cd) | ≤0.05 ppm | <0.05 ppm | ICP-MS |
Mercury (Hg) | Not Detected | Not Detected | Cold Vapor Atomic Absorption (CVAAS) |
Microbiology | — | — | — |
Total Plate Count | <1000 cfu/g | <1000 cfu/g | AOAC 990.12 |
Yeast & Mold | <100 cfu/g | <100 cfu/g | AOAC 997.02 |
E.Coli | Negative | Negative | AOAC 991.14 |
Salmonella | Negative | Negative | ISO 6579 |
S.Aureus | Negative | Negative | USP<62> |
Residual Pesticides | — | — | — |
Pesticides | Negative | Negative | GC-MS Screening |
Conclusion | Conforms to Specification | — | — |
Lycopene — Innovations in Processing and Multidimensional Applications of a Natural Antioxidant |
As one of the most potent naturally occurring antioxidant carotenoids, lycopene (CAS 502-65-8) has drawn increasing attention for its health benefits and wide range of applications. The optimization of its production process is critical in determining both product purity and bioactivity. This article focuses on the industrial production of lycopene supplements and food additives, analyzing the technological advancements that empower its journey from natural extraction to high-value applications.
Core Technologies: Efficient Extraction and Stability Enhancement |
1. Targeted Extraction from Natural Sources
Raw Material Selection: Prioritize tomato varieties with high lycopene content (e.g., cherry tomatoes, processing tomatoes), or utilize by-products from lycopene-rich foods such as watermelon and red guava, with raw material lycopene content ≥ 0.1%.
Supercritical CO₂ Extraction: Operated at 40–60°C and 300–400 bar, this method selectively extracts lipophilic compounds while avoiding thermal degradation, increasing yield by up to 30%.
Enzymatic Cell Wall Disruption: A combination of cellulase and pectinase enzymes is used to break down plant cell walls, enabling lycopene release and achieving extraction efficiency above 95%.
2. Purification and Stability Enhancement
Molecular Distillation: Removes oils, waxes, and impurities such as lutein, yielding a high-purity Lycopene CAS 502-65-8 standard (≥95%).
Microencapsulation Technology: Encapsulation with β-cyclodextrin or phospholipids addresses lycopene’s sensitivity to light and heat, extending shelf life at room temperature to up to 24 months.
Nanoemulsification: Produces water-dispersible nanoemulsions, overcoming lycopene’s lipophilic limitations and enabling its use as a food additive in beverages and dairy products.
Process Advantages: From Natural Source to Functional Ingredient |
1. High Bioavailability Design
Synergistic Formulations: Combined with Vitamin E, selenium, and other antioxidants (e.g., best lycopene supplement for heart health), these formulations enhance antioxidant network effects, with ORAC values ≥ 8000 μmol TE/g.
Precision Dosage: Based on studies on lycopene dosage for antioxidant benefits, standard capsules contain 5–30 mg, with options for customized formulations.
2. Green Production Systems
Solvent Recovery: Closed-loop systems recover ≥98% of ethanol and hexane, adhering to green chemistry principles.
By-product Utilization: Tomato pomace is converted into dietary fiber, achieving zero-waste production.
Quality Control and Global Compliance |
End-to-End Quality Assurance
HPLC-DAD Testing: Quantifies lycopene isomers (≥80% all-trans isomer), ensuring lycopene antioxidant activity.
Safety Evaluation: In line with lycopene side effects and safety guidelines, heavy metals (Pb < 0.1 ppm), pesticide residues (non-detectable), and microbiological testing are rigorously controlled.
Certifications and Standards
Complies with FDA GRAS status, EU Novel Food regulation, and China’s GB 2760 Food Additive Use Standard.
Certified under ISO 22000, HALAL, and KOSHER systems for global market access.
Application Scenarios: From Dietary Supplements to Functional Foods |
1. Health Food Development
Cardiovascular Support: Clinical studies show that 15 mg of daily lycopene supplement intake can reduce LDL oxidation risk by 22%.
Skin Photoprotection: Combined with collagen and hyaluronic acid in nutricosmetics to reduce UV-induced free radical damage.
2. Food Industry Innovation
Natural Colorant (E160d): Nanoemulsification enables vibrant red coloration in beverages and confectionery, replacing synthetic dyes.
Functional Dairy Products: Lycopene fortification in yogurt and milk powder enhances antioxidant properties, targeting aging and sports nutrition markets.
| Product Information |
Product Name: | Lycopene |
Synonyms: | 4,4-CAROTENE;LYCOSOURCE;LYCOPENE;JARCOPENE(TM);2,6,10,14,19,23,27,31-OCTAMETHYL-DOTRIACONTA-2,6,8,10,12,14,16,18,20,22,24,26,30-TRIDECAENE;PSI,PSI-CAROTENE;Y,Y-CAROTENE;E 160d |
CAS: | 502-65-8 |
MF: | C40H56 |
MW: | 536.87 |
EINECS: | 207-949-1 |
| |
| COA Of Lycopene |
Item | Specification | Result | Test Method |
Physical Properties | — | — | — |
Appearance | Dark Red Powder | Complies | Visual Inspection |
Odor | Characteristic | Complies | Organoleptic Test |
Sieve Analysis | NLT 100% pass 80 mesh | Complies | USP<786> Sieve Test |
Chemical Analysis | — | — | — |
Assay (Lycopene by HPLC) | ≥10% | 10.35% | HPLC |
Moisture | ≤3% | 1.95% | Karl Fischer Titration |
Ash | ≤1% | 0.53% | USP<281> Gravimetric Analysis |
Heavy Metals | — | — | — |
Heavy Metals (Total) | ≤10 ppm | <10 ppm | ICP-MS |
Arsenic (As) | ≤2 ppm | <2 ppm | ICP-MS |
Lead (Pb) | ≤1 ppm | <1 ppm | Atomic Absorption Spectroscopy (AAS) |
Cadmium (Cd) | ≤0.05 ppm | <0.05 ppm | ICP-MS |
Mercury (Hg) | Not Detected | Not Detected | Cold Vapor Atomic Absorption (CVAAS) |
Microbiology | — | — | — |
Total Plate Count | <1000 cfu/g | <1000 cfu/g | AOAC 990.12 |
Yeast & Mold | <100 cfu/g | <100 cfu/g | AOAC 997.02 |
E.Coli | Negative | Negative | AOAC 991.14 |
Salmonella | Negative | Negative | ISO 6579 |
S.Aureus | Negative | Negative | USP<62> |
Residual Pesticides | — | — | — |
Pesticides | Negative | Negative | GC-MS Screening |
Conclusion | Conforms to Specification | — | — |
Lycopene — Innovations in Processing and Multidimensional Applications of a Natural Antioxidant |
As one of the most potent naturally occurring antioxidant carotenoids, lycopene (CAS 502-65-8) has drawn increasing attention for its health benefits and wide range of applications. The optimization of its production process is critical in determining both product purity and bioactivity. This article focuses on the industrial production of lycopene supplements and food additives, analyzing the technological advancements that empower its journey from natural extraction to high-value applications.
Core Technologies: Efficient Extraction and Stability Enhancement |
1. Targeted Extraction from Natural Sources
Raw Material Selection: Prioritize tomato varieties with high lycopene content (e.g., cherry tomatoes, processing tomatoes), or utilize by-products from lycopene-rich foods such as watermelon and red guava, with raw material lycopene content ≥ 0.1%.
Supercritical CO₂ Extraction: Operated at 40–60°C and 300–400 bar, this method selectively extracts lipophilic compounds while avoiding thermal degradation, increasing yield by up to 30%.
Enzymatic Cell Wall Disruption: A combination of cellulase and pectinase enzymes is used to break down plant cell walls, enabling lycopene release and achieving extraction efficiency above 95%.
2. Purification and Stability Enhancement
Molecular Distillation: Removes oils, waxes, and impurities such as lutein, yielding a high-purity Lycopene CAS 502-65-8 standard (≥95%).
Microencapsulation Technology: Encapsulation with β-cyclodextrin or phospholipids addresses lycopene’s sensitivity to light and heat, extending shelf life at room temperature to up to 24 months.
Nanoemulsification: Produces water-dispersible nanoemulsions, overcoming lycopene’s lipophilic limitations and enabling its use as a food additive in beverages and dairy products.
Process Advantages: From Natural Source to Functional Ingredient |
1. High Bioavailability Design
Synergistic Formulations: Combined with Vitamin E, selenium, and other antioxidants (e.g., best lycopene supplement for heart health), these formulations enhance antioxidant network effects, with ORAC values ≥ 8000 μmol TE/g.
Precision Dosage: Based on studies on lycopene dosage for antioxidant benefits, standard capsules contain 5–30 mg, with options for customized formulations.
2. Green Production Systems
Solvent Recovery: Closed-loop systems recover ≥98% of ethanol and hexane, adhering to green chemistry principles.
By-product Utilization: Tomato pomace is converted into dietary fiber, achieving zero-waste production.
Quality Control and Global Compliance |
End-to-End Quality Assurance
HPLC-DAD Testing: Quantifies lycopene isomers (≥80% all-trans isomer), ensuring lycopene antioxidant activity.
Safety Evaluation: In line with lycopene side effects and safety guidelines, heavy metals (Pb < 0.1 ppm), pesticide residues (non-detectable), and microbiological testing are rigorously controlled.
Certifications and Standards
Complies with FDA GRAS status, EU Novel Food regulation, and China’s GB 2760 Food Additive Use Standard.
Certified under ISO 22000, HALAL, and KOSHER systems for global market access.
Application Scenarios: From Dietary Supplements to Functional Foods |
1. Health Food Development
Cardiovascular Support: Clinical studies show that 15 mg of daily lycopene supplement intake can reduce LDL oxidation risk by 22%.
Skin Photoprotection: Combined with collagen and hyaluronic acid in nutricosmetics to reduce UV-induced free radical damage.
2. Food Industry Innovation
Natural Colorant (E160d): Nanoemulsification enables vibrant red coloration in beverages and confectionery, replacing synthetic dyes.
Functional Dairy Products: Lycopene fortification in yogurt and milk powder enhances antioxidant properties, targeting aging and sports nutrition markets.
