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| Product Information |
Product name | 5-Bromo-2-chlorobenzoic acid |
Synonyms | 5-bromo-2-chloro-benzoate;5-bromo-2-chloro-benzoic acid;2-Chloro-5-bromobenzoic acid;5-Bromo-2-Chloro Benzoic Acid;2-Chloro-5-Bromo Benzoic Acid; |
CAS No. | 21739-92-4 |
Molecular Formula | C7H4BrClO2 |
Molecular Weight | 235.465 |
Quality Standard | 99% up by HPLC |
Appearance | White to off-white powder |
 | |
5-Bromo-2-chlorobenzoic acid – Key Intermediate for SGLT2 Inhibitor Synthesis |
5-Bromo-2-chlorobenzoic acid (CAS 21739-92-4) is a critical pharmaceutical intermediate widely used in the synthesis of Dapagliflozin intermediate and Empagliflozin intermediate, two leading SGLT2 inhibitors for type 2 diabetes treatment. With the increasing demand for safe and effective antidiabetic drugs, high-quality production of this intermediate has become essential for global supply chains.
Production & Synthesis Process |
The 5-Bromo-2-chlorobenzoic acid synthesis route typically involves selective halogenation of 2-chlorobenzoic acid, followed by purification through controlled crystallization and recrystallization to achieve consistent purity. Advanced process controls ensure batch-to-batch reproducibility and compliance with pharmaceutical standards.
As part of our GMP pharmaceutical intermediates production, we implement:
Strict raw material quality control
Multi-step synthesis optimization to maximize yield
Analytical testing (HPLC, NMR, MS) for structure and purity verification
Scalable manufacturing capacity from pilot to commercial batches
Our pharmaceutical intermediate factory operates under GMP and ISO guidelines, ensuring international regulatory compliance.
Applications & Market Relevance |
Dapagliflozin Intermediate
A primary precursor in the synthesis of Dapagliflozin, a first-in-class SGLT2 inhibitor used for blood glucose management.
Empagliflozin Intermediate
Serves as a building block for Empagliflozin, another widely prescribed SGLT2 inhibitor with proven cardiovascular benefits.
Broader Pharmaceutical Use
As an aryl halogenated acid, it can also serve as a structural scaffold for developing new antidiabetic and cardiovascular drug candidates.
Why Partner With Us? |
High purity 5-Bromo-2-chlorobenzoic acid supplier with consistent ≥99% quality
Expertise in halogenated benzoic acid derivatives
Full regulatory and technical documentation (COA, MSDS, synthesis route details)
Trusted China pharmaceutical intermediates manufacturer with global export experience
Comprehensive CDMO & GMP pharmaceutical intermediates services for custom synthesis
5-Bromo-2-chlorobenzoic acid is a cornerstone intermediate for next-generation diabetes therapies. By ensuring reliable sourcing, optimized production, and global supply capability, we support pharmaceutical companies in advancing both Dapagliflozin and Empagliflozin projects.
| Product Information |
Product name | 5-Bromo-2-chlorobenzoic acid |
Synonyms | 5-bromo-2-chloro-benzoate;5-bromo-2-chloro-benzoic acid;2-Chloro-5-bromobenzoic acid;5-Bromo-2-Chloro Benzoic Acid;2-Chloro-5-Bromo Benzoic Acid; |
CAS No. | 21739-92-4 |
Molecular Formula | C7H4BrClO2 |
Molecular Weight | 235.465 |
Quality Standard | 99% up by HPLC |
Appearance | White to off-white powder |
| |
5-Bromo-2-chlorobenzoic acid – Key Intermediate for SGLT2 Inhibitor Synthesis |
5-Bromo-2-chlorobenzoic acid (CAS 21739-92-4) is a critical pharmaceutical intermediate widely used in the synthesis of Dapagliflozin intermediate and Empagliflozin intermediate, two leading SGLT2 inhibitors for type 2 diabetes treatment. With the increasing demand for safe and effective antidiabetic drugs, high-quality production of this intermediate has become essential for global supply chains.
Production & Synthesis Process |
The 5-Bromo-2-chlorobenzoic acid synthesis route typically involves selective halogenation of 2-chlorobenzoic acid, followed by purification through controlled crystallization and recrystallization to achieve consistent purity. Advanced process controls ensure batch-to-batch reproducibility and compliance with pharmaceutical standards.
As part of our GMP pharmaceutical intermediates production, we implement:
Strict raw material quality control
Multi-step synthesis optimization to maximize yield
Analytical testing (HPLC, NMR, MS) for structure and purity verification
Scalable manufacturing capacity from pilot to commercial batches
Our pharmaceutical intermediate factory operates under GMP and ISO guidelines, ensuring international regulatory compliance.
Applications & Market Relevance |
Dapagliflozin Intermediate
A primary precursor in the synthesis of Dapagliflozin, a first-in-class SGLT2 inhibitor used for blood glucose management.
Empagliflozin Intermediate
Serves as a building block for Empagliflozin, another widely prescribed SGLT2 inhibitor with proven cardiovascular benefits.
Broader Pharmaceutical Use
As an aryl halogenated acid, it can also serve as a structural scaffold for developing new antidiabetic and cardiovascular drug candidates.
Why Partner With Us? |
High purity 5-Bromo-2-chlorobenzoic acid supplier with consistent ≥99% quality
Expertise in halogenated benzoic acid derivatives
Full regulatory and technical documentation (COA, MSDS, synthesis route details)
Trusted China pharmaceutical intermediates manufacturer with global export experience
Comprehensive CDMO & GMP pharmaceutical intermediates services for custom synthesis
5-Bromo-2-chlorobenzoic acid is a cornerstone intermediate for next-generation diabetes therapies. By ensuring reliable sourcing, optimized production, and global supply capability, we support pharmaceutical companies in advancing both Dapagliflozin and Empagliflozin projects.
