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| Product Information |
Product name | Z-D-ARG(PMC)-OH CHA; Z-Amino Acids and Derivatives; Z-Amino acid series; Protect amino acid |
Other names | Z-N-OMEGA-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL)-D-ARGININE CYCLOHEXYLAMMONIUM SALT;Z-D-ARG(PMC)-OH CHA;Z-D-ARGININE(PMC)-OH CHA;N-ALPHA-CARBOBENZOXY-N-OMEGA-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL)-D-ARGININE CYCLOHEXYLAMMONIUM SALT;N-ALPHA-CBZ-NG-2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL-D-ARGININE CYCLOHEXYLAMMONIUM SALT; Z-D-Arg(Pmc)-OH;Nalpha-Z-Nomega-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine cyclohexylammonium salt |
CAS No. | 200191-08-8 |
Molecular Formula | C34H51N5O7S |
Molecular Weight | 673.86 |
Quality Standard | 99% up by HPLC |
Appearance | White powder |
| COA of Z-D-ARG(PMC)-OH CHA |
ITEMS | SPECIFICATION |
Appearance | White to off-white powder |
Appearance of solution | Clear colorless solution in methanol (50 mg/mL) |
Purity (HPLC) | ≥ 98% |
Purity (TLC) | ≥ 98% |
Related impurities | ≤ 0.2% Z-D-Arg-OH |
| Z-D-Arg(PMC)-OH·CHA – High-Purity D-Arginine Building Block for Peptide Synthesis |
Z-D-Arg(PMC)-OH·CHA (CAS 200191-08-8) is a specialized D-arginine PMC protected derivative and essential D-arginine building block widely used in advanced peptide synthesis. With high structural stability and selective protection, this intermediate supports precise coupling steps in complex peptide drug development. As an experienced partner in pharmaceutical intermediate CDMO, we provide scalable production and global supply with consistent quality.
| Production & Process Development |
The manufacturing of Z-D-Arg(PMC)-OH·CHA involves precise protection of the guanidino group with Pmc (2,2,5,7,8-pentamethylchroman-6-sulfonyl) and N-terminal blocking with benzyloxycarbonyl (Z). This dual protection ensures controlled reactivity during peptide chain assembly, minimizing side reactions. The product is typically isolated as a cyclohexylammonium salt, providing improved crystallinity and handling stability.
Our CDMO contract manufacturing for pharmaceutical intermediate services include:
Process optimization for high yield and low impurity profile
Purification via preparative chromatography and recrystallization
Analytical verification by HPLC, NMR, and MS to guarantee purity ≥98%
Flexible scale-up from gram to multi-kilogram production
| Applications & Uses |
Peptide Synthesis Intermediate
Widely recognized as a Z-D-Arg(PMC)-OH·CHA peptide synthesis intermediate, it is crucial in assembling cyclic peptides and bioactive oligopeptides with D-configuration residues.
Protected D-Arginine Derivative
The Z-D-Arg(PMC)-OH·CHA D-arginine derivative purity ≥98% ensures reliable performance in pharmaceutical research, particularly in peptides targeting oncology, cardiovascular, and antiviral applications.
Global Supply & Customization
As a Z-D-Arg(PMC)-OH·CHA cyclohexylammonium salt supplier, we support both catalog supply and tailor-made synthesis, including customized packaging and technical documentation (COA, SDS).
| Why Partner With Us? |
Expertise in protected arginine building blocks
Integrated pharmaceutical intermediate CDMO solutions
End-to-end support: process development, analytical validation, and regulatory documentation
Scalable, consistent, and reliable global supply
Z-D-Arg(PMC)-OH·CHA is more than just a protected amino acid—it is a cornerstone intermediate enabling precision in modern peptide synthesis. Our advanced CDMO platform ensures consistent quality, scalable production, and technical support tailored to your R&D and commercial needs.
| Product Information |
Product name | Z-D-ARG(PMC)-OH CHA; Z-Amino Acids and Derivatives; Z-Amino acid series; Protect amino acid |
Other names | Z-N-OMEGA-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL)-D-ARGININE CYCLOHEXYLAMMONIUM SALT;Z-D-ARG(PMC)-OH CHA;Z-D-ARGININE(PMC)-OH CHA;N-ALPHA-CARBOBENZOXY-N-OMEGA-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL)-D-ARGININE CYCLOHEXYLAMMONIUM SALT;N-ALPHA-CBZ-NG-2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL-D-ARGININE CYCLOHEXYLAMMONIUM SALT; Z-D-Arg(Pmc)-OH;Nalpha-Z-Nomega-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine cyclohexylammonium salt |
CAS No. | 200191-08-8 |
Molecular Formula | C34H51N5O7S |
Molecular Weight | 673.86 |
Quality Standard | 99% up by HPLC |
Appearance | White powder |
| COA of Z-D-ARG(PMC)-OH CHA |
ITEMS | SPECIFICATION |
Appearance | White to off-white powder |
Appearance of solution | Clear colorless solution in methanol (50 mg/mL) |
Purity (HPLC) | ≥ 98% |
Purity (TLC) | ≥ 98% |
Related impurities | ≤ 0.2% Z-D-Arg-OH |
| Z-D-Arg(PMC)-OH·CHA – High-Purity D-Arginine Building Block for Peptide Synthesis |
Z-D-Arg(PMC)-OH·CHA (CAS 200191-08-8) is a specialized D-arginine PMC protected derivative and essential D-arginine building block widely used in advanced peptide synthesis. With high structural stability and selective protection, this intermediate supports precise coupling steps in complex peptide drug development. As an experienced partner in pharmaceutical intermediate CDMO, we provide scalable production and global supply with consistent quality.
| Production & Process Development |
The manufacturing of Z-D-Arg(PMC)-OH·CHA involves precise protection of the guanidino group with Pmc (2,2,5,7,8-pentamethylchroman-6-sulfonyl) and N-terminal blocking with benzyloxycarbonyl (Z). This dual protection ensures controlled reactivity during peptide chain assembly, minimizing side reactions. The product is typically isolated as a cyclohexylammonium salt, providing improved crystallinity and handling stability.
Our CDMO contract manufacturing for pharmaceutical intermediate services include:
Process optimization for high yield and low impurity profile
Purification via preparative chromatography and recrystallization
Analytical verification by HPLC, NMR, and MS to guarantee purity ≥98%
Flexible scale-up from gram to multi-kilogram production
| Applications & Uses |
Peptide Synthesis Intermediate
Widely recognized as a Z-D-Arg(PMC)-OH·CHA peptide synthesis intermediate, it is crucial in assembling cyclic peptides and bioactive oligopeptides with D-configuration residues.
Protected D-Arginine Derivative
The Z-D-Arg(PMC)-OH·CHA D-arginine derivative purity ≥98% ensures reliable performance in pharmaceutical research, particularly in peptides targeting oncology, cardiovascular, and antiviral applications.
Global Supply & Customization
As a Z-D-Arg(PMC)-OH·CHA cyclohexylammonium salt supplier, we support both catalog supply and tailor-made synthesis, including customized packaging and technical documentation (COA, SDS).
| Why Partner With Us? |
Expertise in protected arginine building blocks
Integrated pharmaceutical intermediate CDMO solutions
End-to-end support: process development, analytical validation, and regulatory documentation
Scalable, consistent, and reliable global supply
Z-D-Arg(PMC)-OH·CHA is more than just a protected amino acid—it is a cornerstone intermediate enabling precision in modern peptide synthesis. Our advanced CDMO platform ensures consistent quality, scalable production, and technical support tailored to your R&D and commercial needs.
