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| Product Information |
Product name | Nattokinase |
CAS No. | 133876-92-3 |
Source | Natto Extract |
Quality | 2000fu/g; 4000fu/g; 6000fu/g; 20000fu/g |
Appearance | Light yellow to off-white powder |
| COA Of Nattokinase |
Item | Specification | Result | Test Method |
Maker Compounds | ≥20,000 FU/g | Conforms | Enzyme Activity Assay |
Organoleptic | — | — | — |
Appearance | Light yellow to off-white fine powder | Conforms | Visual Inspection |
Odor | Characteristic | Conforms | Organoleptic Evaluation |
Taste | Characteristic | Conforms | Sensory Analysis |
Excipient | None | Conforms | Chromatographic Screening |
Physical Characteristics | — | — | — |
Particle Size | ≥100% pass 80 mesh | Conforms | Sieve Analysis (USP<786>) |
Loss on Drying | ≤8.0% | 5.2% | Gravimetric Analysis (105°C) |
Ash | ≤5.0% | 2.9% | USP<281> Gravimetric Analysis |
Bulk Density | 40-60 g/100ml | 50 g/100ml | Volumetric Measurement |
Heavy Metals | — | — | — |
Total Heavy Metals | ≤10 ppm | Conforms | ICP-MS |
Arsenic | ≤2 ppm | Conforms | ICP-MS |
Lead | ≤2 ppm | Conforms | Atomic Absorption Spectroscopy (AAS) |
Microbiological Tests | — | — | — |
Total Plate Count | ≤1,000 cfu/g | Conforms | AOAC 990.12 |
Total Yeast & Mold | ≤100 cfu/g | Conforms | AOAC 997.02 |
E. Coli | Negative | Negative | ISO 16654 |
Salmonella | Negative | Negative | ISO 6579 |
Staphylococcus | Negative | Negative | USP<62> |
Assay | — | — | — |
Assay (Anhydrous, Acetic Acid-free) | 97.0-103.0% | 99.5% | HPLC |
Conclusion | Complies with Specifications | — | — |
Nattokinase – Natural Enzyme for Cardiovascular Health |
Nattokinase (CAS 133876-92-3) is a fibrinolytic enzyme extracted from the traditional Japanese food Natto. Recognized for its role in supporting cardiovascular function, it is widely used in dietary formulations as a nattokinase supplement. With extensive clinical research highlighting nattokinase benefits in promoting healthy blood circulation and reducing clot formation, it has become one of the most trusted natural food supplement ingredients in the nutraceutical market.
Production & Manufacturing Process |
Our nattokinase enzyme is produced through a controlled fermentation process of Bacillus subtilis natto, followed by advanced purification to ensure consistent activity and safety:
Fermentation Technology: Optimized strains for stable and high-yield production.
Purification: Multi-step filtration and chromatography to isolate bioactive nattokinase enzyme with minimal impurities.
Activity Control: Standardized fibrinolytic activity units (FU) for reproducible efficacy across batches.
Quality Compliance: Manufactured under strict GMP for food supplements with validated HACCP controls.
Supplement Raw Materials Supply: Available in powder or granule forms tailored for capsules, tablets, and functional foods.
Applications & Benefits |
Cardiovascular Health:
Promoted as the best nattokinase supplement for heart health, supporting blood flow and reducing risks of thrombosis.
Mechanism of Action:
How does nattokinase work? It directly degrades fibrin, enhances plasmin production, and supports the body’s natural clot-dissolving pathways.
Nutraceuticals & Functional Foods:
Popular in formulations targeting healthy circulation, cholesterol management, and blood pressure balance.
Synergistic Formulations:
Often combined with omega-3, CoQ10, or vitamin K2 for enhanced cardiovascular support.
Why Partner With Us? |
Reliable supplement raw materials sourcing with full traceability
Natural food supplement ingredients manufactured under strict GMP
Batch-to-batch consistency with high enzyme activity and purity
Flexible CDMO services for customized capsule, tablet, or blend formulations
Nattokinase stands as a clinically supported enzyme supplement that combines traditional wisdom with modern bioprocessing. With proven nattokinase benefits for cardiovascular protection, we deliver premium-grade raw materials backed by GMP-certified food supplement manufacturing to meet global nutraceutical demands.
| Product Information |
Product name | Nattokinase |
CAS No. | 133876-92-3 |
Source | Natto Extract |
Quality | 2000fu/g; 4000fu/g; 6000fu/g; 20000fu/g |
Appearance | Light yellow to off-white powder |
| COA Of Nattokinase |
Item | Specification | Result | Test Method |
Maker Compounds | ≥20,000 FU/g | Conforms | Enzyme Activity Assay |
Organoleptic | — | — | — |
Appearance | Light yellow to off-white fine powder | Conforms | Visual Inspection |
Odor | Characteristic | Conforms | Organoleptic Evaluation |
Taste | Characteristic | Conforms | Sensory Analysis |
Excipient | None | Conforms | Chromatographic Screening |
Physical Characteristics | — | — | — |
Particle Size | ≥100% pass 80 mesh | Conforms | Sieve Analysis (USP<786>) |
Loss on Drying | ≤8.0% | 5.2% | Gravimetric Analysis (105°C) |
Ash | ≤5.0% | 2.9% | USP<281> Gravimetric Analysis |
Bulk Density | 40-60 g/100ml | 50 g/100ml | Volumetric Measurement |
Heavy Metals | — | — | — |
Total Heavy Metals | ≤10 ppm | Conforms | ICP-MS |
Arsenic | ≤2 ppm | Conforms | ICP-MS |
Lead | ≤2 ppm | Conforms | Atomic Absorption Spectroscopy (AAS) |
Microbiological Tests | — | — | — |
Total Plate Count | ≤1,000 cfu/g | Conforms | AOAC 990.12 |
Total Yeast & Mold | ≤100 cfu/g | Conforms | AOAC 997.02 |
E. Coli | Negative | Negative | ISO 16654 |
Salmonella | Negative | Negative | ISO 6579 |
Staphylococcus | Negative | Negative | USP<62> |
Assay | — | — | — |
Assay (Anhydrous, Acetic Acid-free) | 97.0-103.0% | 99.5% | HPLC |
Conclusion | Complies with Specifications | — | — |
Nattokinase – Natural Enzyme for Cardiovascular Health |
Nattokinase (CAS 133876-92-3) is a fibrinolytic enzyme extracted from the traditional Japanese food Natto. Recognized for its role in supporting cardiovascular function, it is widely used in dietary formulations as a nattokinase supplement. With extensive clinical research highlighting nattokinase benefits in promoting healthy blood circulation and reducing clot formation, it has become one of the most trusted natural food supplement ingredients in the nutraceutical market.
Production & Manufacturing Process |
Our nattokinase enzyme is produced through a controlled fermentation process of Bacillus subtilis natto, followed by advanced purification to ensure consistent activity and safety:
Fermentation Technology: Optimized strains for stable and high-yield production.
Purification: Multi-step filtration and chromatography to isolate bioactive nattokinase enzyme with minimal impurities.
Activity Control: Standardized fibrinolytic activity units (FU) for reproducible efficacy across batches.
Quality Compliance: Manufactured under strict GMP for food supplements with validated HACCP controls.
Supplement Raw Materials Supply: Available in powder or granule forms tailored for capsules, tablets, and functional foods.
Applications & Benefits |
Cardiovascular Health:
Promoted as the best nattokinase supplement for heart health, supporting blood flow and reducing risks of thrombosis.
Mechanism of Action:
How does nattokinase work? It directly degrades fibrin, enhances plasmin production, and supports the body’s natural clot-dissolving pathways.
Nutraceuticals & Functional Foods:
Popular in formulations targeting healthy circulation, cholesterol management, and blood pressure balance.
Synergistic Formulations:
Often combined with omega-3, CoQ10, or vitamin K2 for enhanced cardiovascular support.
Why Partner With Us? |
Reliable supplement raw materials sourcing with full traceability
Natural food supplement ingredients manufactured under strict GMP
Batch-to-batch consistency with high enzyme activity and purity
Flexible CDMO services for customized capsule, tablet, or blend formulations
Nattokinase stands as a clinically supported enzyme supplement that combines traditional wisdom with modern bioprocessing. With proven nattokinase benefits for cardiovascular protection, we deliver premium-grade raw materials backed by GMP-certified food supplement manufacturing to meet global nutraceutical demands.
