1. Customizable compounds:
·Chiral compounds
·Prostaglandin series products
·Pharmaceutical intermediates(including Amino-, Nitro-, Hydroxyl-, Borono-,etc )
·Develop non-patent infringement routes
·Separation and purification of fermentation products
·Enzyme catalysis / Enzymatic resolution
2. Reactions:
·Grignard reaction
·Oxidation / Reduction
·Ring closure reaction
·Condensation reaction
·Halogenation
·Nitration
·Amination
·Enzyme catalysis / Enzymatic resolution
·Continuous flow reaction
3. Special facilities that can meet these circumstances:
·High vacuum (reach 1 mmHg)
·Low temperature (reach -100℃)
·High temperature (reach 200℃)
4. Available sites/lines:
·cGMP manufacturing site for custom manufacturing
·High active API (to OEB5) production line (20L–100L)
·Continuous Flow Technology(pipeline)
5.Rockypharm Successful CDMO Project Examples
Case 1:
Product: Paclitaxel Side Chain /(3R,4S)-1-Benzoyl-3-(1-Ethoxyethoxy)-4-Phenyl-2-Azetidinone
CAS: 201856-53-3
Purity: ≥98% (HPLC)