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| Product Information |
Product name | Asciminib |
Synonyms | ABL001;ABL-001;ABL-001; AB -001; ABL001; ASCIMINIB; ASCIMINIB FREE BASE;;asciminib free base;(R)-N- (4-(CHLORODIFLUOROMETHOXY)PHENYL)- 6-(3- HYDROXYPYRROLIDIN-1- YL)-5- (1H-PYRAZOL- 5-YL)NICOTI;(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide;ABL-001;Asciminib;EOS-61420 |
CAS No. | 1492952-76-7 |
Molecular Formula | C20H18ClF2N5O3 |
Molecular Weight | 449.84 |
Quality Standard | 99.5% up by HPLC,ISOMER N.D. |
Appearance | White to off-white powder |
Asciminib Base – High-Purity Pharmaceutical API for Advanced CML Therapy |
Asciminib Base (CAS 1492952-76-7) is an innovative targeted anticancer compound developed for the treatment of chronic myeloid leukemia (CML). As a next-generation STAMP inhibitor, it offers a distinct mechanism of action by selectively targeting the ABL myristoyl pocket. With growing demand in oncology drug development, Asciminib API has become an important product for pharmaceutical manufacturers. Our Asciminib powder is designed to meet the quality and consistency requirements of pharmaceutical research and API production.
Production & Manufacturing Process |
Our Asciminib Base manufacturing process focuses on synthetic precision, impurity control, and scalable production to ensure consistent pharmaceutical-grade quality.
Multi-Step Chemical Synthesis: The production route involves carefully controlled reactions using selected aromatic and heterocyclic intermediates to construct the molecular framework of Asciminib.
Reaction Optimization: Precise control of temperature, reaction time, pH, and reagent ratios helps improve conversion efficiency and minimize unwanted by-products.
Purification Technology: Advanced crystallization, filtration, and solvent removal processes help obtain high-purity Asciminib with consistent physical and chemical properties.
Quality Control: HPLC, LC-MS, and NMR analytical methods are applied to evaluate purity, molecular identity, and process-related impurities.
Production Scalability: Optimized manufacturing procedures support reproducible production from laboratory batches to larger commercial requirements.
Applications & Pharmaceutical Value |
Chronic Myeloid Leukemia Treatment: Asciminib is used in targeted therapy for Philadelphia chromosome-positive CML, particularly in patients meeting the approved treatment criteria.
Targeted Oncology Research: Its selective inhibition of the ABL myristoyl pocket makes it valuable for research into BCR-ABL1 signaling pathways and drug resistance.
Pharmaceutical Development: High-quality Asciminib pharmaceutical intermediate materials support process development, analytical research, and API manufacturing.
Bulk Pharmaceutical Supply: Consistent product quality and scalable production make it suitable for pharmaceutical companies developing targeted oncology medicines.
Why Partner With Us? |
Professional Asciminib API manufacturer with expertise in complex pharmaceutical synthesis.
Reliable supply of High purity Asciminib API for pharmaceutical development.
Flexible production capacity as an Asciminib bulk powder supplier.
Controlled manufacturing processes aligned with the requirements of an Asciminib GMP manufacturer.
Focus on batch consistency, impurity management, and long-term supply stability.
Asciminib Base represents an important advancement in targeted leukemia therapy. Through optimized chemical synthesis, advanced purification technology, and strict quality management, we aim to provide reliable Asciminib API solutions for global pharmaceutical partners.
Contact us today to discuss product specifications, bulk supply availability, and customized manufacturing requirements.
