Views: 0 Author: Site Editor Publish Time: 2025-10-09 Origin: Site
Varicose veins are one of the most common vascular conditions worldwide. According to Circulation, a journal jointly published by the American Heart Association (AHA), more than 23% of adults suffer from some degree of venous insufficiency — meaning nearly one in four people experience varicose veins. But what exactly causes this condition, and how can Diosmin — a natural flavonoid widely used in Diosmin supplements and pharmaceutical raw material suppliers — help improve venous health?
Veins in the lower limbs contain valves that ensure one-way blood flow toward the heart. When these valves weaken or become damaged, blood begins to flow backward, causing it to pool inside the veins. This increases venous pressure, leading to swelling, dilation, and visible bulging veins — the classic symptoms of varicose veins.
Key contributing factors include:
Genetic predisposition: Family history significantly increases the risk.
Pregnancy and obesity: Increased abdominal pressure puts extra strain on leg veins.
Aging: Valve elasticity declines with time, promoting blood reflux.
Smoking: Nicotine triggers inflammation and damages vascular walls.
Prolonged sitting or standing: Limited leg movement prevents effective venous return.
Diosmin (CAS 520-27-4) is a naturally occurring flavonoid glycoside extracted from citrus peels. It functions as a venotonic and vascular protector, improving blood circulation and reducing inflammation in venous disorders. High-quality Natural Diosmin from citrus extraction has become an essential active pharmaceutical ingredient (API) for managing chronic venous diseases.
In modern pharmaceutical production, Micronized Diosmin — also known as Micronized Purified Diosmin — is preferred for its enhanced absorption and bioavailability. Through micronization, particle size is significantly reduced, allowing the compound to dissolve faster and act more effectively within the venous system.
Diosmin works through several mechanisms that directly target the pathophysiology of venous insufficiency:
Enhances venous tone: Strengthens smooth muscle in vein walls, improving elasticity and reducing venous pooling.
Improves lymphatic drainage: Boosts lymphatic flow, helping eliminate tissue fluid retention and swelling.
Reduces capillary permeability: Prevents leakage, alleviating edema and skin complications.
Anti-inflammatory and antioxidant effects: Inhibits inflammatory mediators (like TNF-α and IL-6) that damage venous tissues.
Recent research on Micronized Diosmin absorption improvement and MPFF mechanisms (Micronized Purified Flavonoid Fraction) confirms that Diosmin not only improves venous tone but also enhances lymphatic drainage, offering dual protection for circulatory health.
For pharmaceutical companies and active pharmaceutical ingredient manufacturers in China, producing High Purity Diosmin 99% Powder has become a key focus. As demand for Diosmin API grows, leading API suppliers and pharmaceutical raw material suppliers continue to optimize production efficiency and ensure compliance with international pharmacopeia standards.
These advancements enable consistent global supply of Diosmin supplements used in the management of chronic venous disease, varicose veins, and related circulatory conditions.
Varicose veins result from chronic venous valve dysfunction, often worsened by genetics, aging, and lifestyle. Micronized Diosmin, derived naturally from citrus, plays a pivotal role in strengthening vein tone, promoting lymphatic flow, and reducing inflammation, making it one of the most effective natural therapies for venous insufficiency. Supported by modern manufacturing and quality assurance from trusted API manufacturers, Diosmin continues to set the standard for vascular health solutions.
