Views: 0 Author: Site Editor Publish Time: 2026-03-13 Origin: Site
Polydeoxyribonucleotide (PDRN) has become a cornerstone ingredient in advanced skincare and aesthetic medicine due to its powerful regenerative and anti-inflammatory properties. Widely recognized under PDRN (CAS 100403-24-5 / 9007-49-2), this DNA-derived compound is a premium cosmetic raw material used in both injectable treatments and topical formulations.
Today, leading cosmetic raw material suppliers and cosmetic raw material manufacturers in China are focusing on refining the production of high-purity animal-derived Polydeoxyribonucleotide (PDRN), particularly from salmon sources, to meet global demand for safe and effective skin-repair ingredients.
Animal-derived Polydeoxyribonucleotide (PDRN) is typically extracted from salmon or trout DNA. Its molecular structure shares over 95% similarity with human DNA, ensuring excellent biocompatibility and minimal risk of adverse reactions.
Because of this, PDRN is widely used in:
Medical aesthetic injections
Skin repair therapies
High-end cosmetic formulations
Its ability to stimulate tissue regeneration and enhance cellular repair makes it a highly valued active ingredient in both pharmaceutical and cosmetic industries.
The production of high-quality PDRN (CAS 100403-24-5 / 9007-49-2) involves a multi-step, tightly controlled process to ensure purity, safety, and biological activity:
Premium-grade salmon or trout is selected as the primary source. Strict quality control ensures the raw material is free from contaminants such as heavy metals, pathogens, and environmental toxins.
DNA is extracted from fish tissues using advanced biochemical methods. This step isolates high-quality nucleic acids while preserving their structural integrity.
The extracted DNA undergoes controlled enzymatic hydrolysis to produce Polydeoxyribonucleotide (PDRN) fragments of specific molecular weights. This step determines the final application of the product:
~700 kDa: Used in medical devices for tissue regeneration and bone repair
350–500 kDa: Pharmaceutical-grade for injection, supporting wound healing and anti-inflammatory effects
<50 kDa: Cosmetic-grade for topical applications, focusing on skin repair and anti-aging
Advanced purification techniques, including ultrafiltration and chromatography, are used to remove proteins, impurities, and endotoxins. This ensures:
High purity (≥99% by HPLC)
Extremely low endotoxin levels (≤0.05 EU/mg for pharmaceutical grade)
The purified PDRN solution is sterilized and converted into powder form through lyophilization. This ensures stability, long shelf life, and ease of formulation.
High-quality Polydeoxyribonucleotide (PDRN) products typically meet the following specifications:
CAS Number: 100403-24-5 / 9007-49-2
Purity: ≥99% (HPLC)
Molecular Weight: Customizable (cosmetic to pharmaceutical grade)
Endotoxin Level: ≤0.05 EU/mg (injectable grade)
Recommended Cosmetic Dosage: 0.02% – 0.2%
Source: Salmon or trout DNA
These specifications ensure that PDRN meets both cosmetic and medical application requirements, providing flexibility for different formulation needs.
As a high-performance cosmetic raw material, animal-derived PDRN is widely used in:
Injectable skin boosters for deep tissue regeneration
Serums and ampoules for anti-aging and repair
Creams and masks for hydration and barrier restoration
Its ability to stimulate collagen production, reduce inflammation, and accelerate healing makes it especially effective for sensitive, damaged, or aging skin.
With growing demand for regenerative skincare ingredients, reliable cosmetic raw material suppliers play a critical role in ensuring consistent quality and supply. In recent years, cosmetic raw material manufacturers in China have become key global partners by offering:
Scalable production capacity
Competitive pricing
Compliance with international standards (ISO, GMP)
Customizable molecular weight and purity levels
This positions China as a leading hub for high-quality Polydeoxyribonucleotide (PDRN) production.
Animal-derived Polydeoxyribonucleotide (PDRN) represents a scientifically advanced cosmetic ingredient with proven regenerative benefits. Through precise extraction, controlled depolymerization, and rigorous purification, manufacturers can deliver high-purity PDRN tailored for both cosmetic and medical applications.
As innovation continues and global demand increases, PDRN will remain a key ingredient in next-generation skincare, supported by trusted cosmetic raw material suppliers and advanced cosmetic raw material manufacturers in China.
